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In-depth assessment of the development process of CRS - providing the best intervention window and rChimeric antigen receptor-modified T cell (CAR-T) therapy is currently a powerful approach to combat hematological malignancies, but cytokine release syndrome (...05-30 -
Off-the-shelf CAR-T cell therapy against host immune rejectionIn recent years, CAR-T cell therapy has become a promising cancer treatment. However, due to the high cost of CAR-T therapy and the differences in patients'...05-15 -
Comparison of CAR-NK cells derived from adult peripheral blood and umbilical cord bloodAmong hematological cancers, acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) are the most common leukemias in children and the elderly...05-15 -
Safety, efficacy, and determinants of allogeneic CAR-NK cell therapy for tumors: a phase 1/2 trialCAR-T cell therapy marks the advent of the era of cell therapy. However, CAR-T cells have their limitations, including treatment costs, manufacturing time, and ...05-15 -
Small extracellular vesicles derived from solid tumors inhibit the efficacy of CAR-T cellsChimeric antigen receptor T-cell ( CAR-T ) therapy has shown significant efficacy in the treatment of hematopoietic tumors. However, their effectiveness in trea...05-15 -
NKG2D-CAR T cell anti-aging researchThe reason why humans die is that exhausted tissues cannot renew themselves forever, and the ability of cells to divide is also limited. Aging is a problem that...05-15 -
CAR T targeting intracellular oncoproteinsCAR - T cell tumor immunotherapy has demonstrated strong anti-tumor efficacy in hematological tumors such as leukemia, but its application in the field of solid...05-15 -
Limitations and breakthrough directions of CAR-T in the treatment of solid tumorsThe incidence and mortality of cancer continue to increase, but effective treatments have not yet been found. Traditional therapies, including surgery, radiothe...05-15 -
Study on CD123-targeted CAR-T cells for the treatment of AMLCAR-T cell therapy is an immunotherapy method that uses genetic engineering technology to modify human T cells so that they can specifically recognize and kill ...05-15 -
CRISPR screening reveals the role of BHLHE40 in mimicking CD8+ T cell exhaustion in vitroT cell exhaustion is a state in which T cells lose function under long-term stimulation of chronic infection and cancer. Its main manifestations are: reduced ...05-15
